{"id":43,"date":"2023-12-19T19:14:57","date_gmt":"2023-12-19T10:14:57","guid":{"rendered":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/?page_id=43"},"modified":"2024-11-20T17:17:19","modified_gmt":"2024-11-20T08:17:19","slug":"publication","status":"publish","type":"page","link":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/publication.html","title":{"rendered":"Publication"},"content":{"rendered":"\n
\u4f50\u85e4\u8b1b\u5e2b\u306e\u7814\u7a76\u696d\u7e3e\u306b\u3064\u3044\u3066\u306fresearchmap<\/a>\u3092\u53c2\u7167\u3057\u3066\u304f\u3055\u3044\u3002\n<\/pre>\n\n\n\n
2025<\/h2>\n\n\n\n
1.Fumito Naganuma<\/strong>, Mudasir Khanday, Sathyajit Sai Bandaru, Whidul Hasan, Kyosuke Hirano<\/strong>,Takeo Yoshikawa<\/strong>,Ramalingam Vetrivelan, Regulation of wakefulness by neurotensin neurons in the lateral hypothalamus, Exp Neurol 383, 115035, 2025 https:\/\/doi.org\/10.1016\/j.expneurol.2024.115035<\/a><\/pre>\n\n\n\n
2024<\/h2>\n\n\n\n
1.Fumito Naganuma<\/strong>,  Birkan Girgin,  Anne Bernadette S Agu,  Kyosuke Hirano<\/strong>, Tadaho Nakamura,  Kazuhiko Yanai,  Ramalingam Vetrivelan,  Takatoshi Mochizuki, Masashi Yanagisawa,  Takeo Yoshikawa<\/strong>, Pharmacological inhibition of histamine N-methyltransferase extends wakefulness and suppresses cataplexy in a mouse model of narcolepsy, Sleep zsae244, 2024 https:\/\/doi.org\/10.1093\/sleep\/zsae244<\/a><\/pre>\n\n\n\n
2023<\/h2>\n\n\n\n
1. Fumito Naganuma<\/strong><\/span>, Daiki Murata, Marie Inoue, Yuri Maehori, Ryuichi Harada, Shozo Furumoto, Yukitsuka Kudo, Tadaho Nakamura, Nobuyuki Okamura,A Novel Near-Infrared Fluorescence Probe THK-565 Enables In Vivo Detection of Amyloid Deposits in Alzheimer's Disease Mouse Model. Mol Imaging Biol 25: 1115-1124, 2023, DOI: 10.1007\/s11307-023-01843-4<\/a>\n2. Kensuke Sakaji, Sara Ebrahimiazar, Yasuhiro Harigae, Kenichi Ishibashi, Takeya Sato, Takeo Yoshikawa<\/strong><\/span>, Gen-ichi Atsumi, Ching-Hwa Sung, Masaki Saito,MAST4 promotes primary ciliary resorption through phosphorylation of Tctex-1, Life Science Alliance 6(11) e202301947-e202301947 2023, DOI: 10.26508\/lsa.202301947<\/a>\n3. Nami Tateyama, Teizo Asano, Tomohiro Tanaka, Yu Isoda, Yuki Okada, Hiyori Kobayashi, Guanjie Li, Ren Nanamiya, Takeo Yoshikawa<\/strong><\/span>, Mika K Kaneko, Hiroyuki Suzuki, Yukinari Kato, Epitope Mapping of Anti-Mouse CCR3 Monoclonal Antibodies (C3Mab-6 and C3Mab-7). Monoclon Antib Immunodiagn Immunother 42(2) 68-72 2023 DOI: 10.1089\/mab.2022.0034<\/a>\n4. Yu Isoda, Tomohiro Tanaka, Hiroyuki Suzuki, Teizo Asano, Kaishi Kitamura, Yuma Kudo, Ryo Ejima, Kazuki Ozawa, Takeo Yoshikawa<\/strong><\/span>, Mika K Kaneko, Yukinari Kato, Epitope Mapping of the Novel Anti-Human CCR9 Monoclonal Antibody (C9Mab-11) by 2\u2009\u00d7\u2009Alanine Scanning. Monoclon Antib Immunodiagn Immunother 42(2) 73-76 2023 DOI: 10.1089\/mab.2022.0035<\/a>\n5. Guanjie Li, Hiroyuki Suzuki, Tomohiro Tanaka, Teizo Asano, Takeo Yoshikawa<\/strong><\/span>, Mika K Kaneko, Yukinari Kato\n, Epitope Mapping of an Anti-EpCAM Monoclonal Antibody (EpMab-37) Using the Alanine Scanning Method.\n Monoclon Antib Immunodiagn Immunother 42(1) 41-47 2023 DOI: 10.3892\/ijmm.2023.5221<\/a>\n<\/pre>\n\n\n\n
2022<\/h2>\n\n\n\n
1. Rina Otsuka, Fumito Naganuma<\/strong><\/span>, Tadaho Nakamura, Hideki Miwa, Rumi Nakayama-Naono, Takuro Matsuzawa, Yurika Komatsu, Yuki Sato, Yuna Takahashi, Haruna Tatsuoka-Kitano, Kazuhiko Yanai, Takeo Yoshikawa*<\/strong><\/span>, Contribution of astrocytic histamine N-methyltransferase to histamine clearance and brain function in mice. Neuropharmacology 212: 109065, 2022, DOI: 10.1016\/j.neuropharm.2022.109065<\/a>\n2. Tomomitsu Iida, Kazuhiko Yanai, Takeo Yoshikawa*<\/strong><\/span>, Histamine and Microglia, Curr Top Behav Neurosci 59: 241-259, 2022, DOI:10.1007\/7854_2022_322<\/a>\n3. Tadaho Nakamura, Fumito Naganuma, Uta Kudomi, Sueji Roh, Kazuhiko Yanai, Takeo Yoshikawa*<\/strong>,<\/span> Oral histidine intake improves working memory through the activation of histaminergic nervous system in mice. Biochem Biophys Res Commun609: 141-148, 2022, DOI: 10.1016\/j.bbrc.2022.04.016<\/a>\n4. Hiyori Kobayashi, Teizo Asano, Hiroyuki Suzuki, Tomohiro Tanaka, Takeo Yoshikawa<\/strong><\/span>, Mika K. Kaneko, Yukinari Kato, Establishment of a Sensitive Monoclonal Antibody Against Mouse CCR9 (C9<\/sub>Mab-24) for Flow Cytometry, Monoclon Antib Immunodiagn Immunother, 42: 15-21, 2022, DOI: 10.1089\/mab.2022.0032<\/a>\n5. Nami Tateyama, Teizo Asano, Hiroyuki Suzuki, Guanjie Li, Takeo Yoshikawa<\/strong><\/span>, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato, Epitope Mapping of Anti-Mouse CCR3 Monoclonal Antibodies Using Flow Cytometry, Antibodies 11: 75, 2022, DOI: 10.3390\/antib11040075<\/a>\n6. Teizo Asano, Tomohiro Tanaka, Hiroyuki Suzuki, Guanjie Li, Tomokazu Ohishi, Manabu Kawada, Takeo Yoshikawa<\/strong><\/span>, Mika K. Kaneko, Yukinari Kato, A Defucosylated Anti-EpCAM Monoclonal Antibody (EpMab-37-mG2a-f) Exerts Antitumor Activity in Xenograft Model, Antibodies 4: 74, 2022, DOI: 10.3390\/antib11040074<\/a>\n7. Ren Nanamiya, Tomokazu Ohishi, Hiroyuki Suzuki, Takuya Mizuno, Takeo Yoshikawa<\/strong><\/span>, Teizo Asano, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato, Defucosylated Mouse-Dog Chimeric Anti-Human Epidermal Growth Factor Receptor 2 Monoclonal Antibody (H77Bf) Exerts Antitumor Activities in Mouse Xenograft Models of Canine Osteosarcoma, Monoclon Antib Immunodiagn Immunother, 42: 27-33, 2022, DOI: 10.1089\/mab.2022.0022<\/a>\n8. Nami Tateyama, Hiroyuki Suzuki, Tomokazu Ohishi, Teizo Asano, Tomohiro Tanaka, Takuya Mizuno, Takeo Yoshikawa<\/strong><\/span>, Manabu Kawada, Mika K. Kaneko, Yukinari Kato, Antitumor Activity of an Anti-EGFR\/HER2 Bispecific Antibody in a Mouse Xenograft Model of Canine Osteosarcoma. Pharmaceutics 14: 2494, 2022, DOI: 10.3390\/pharmaceutics14112494<\/a>\n9. Teizo Asano, Tomohiro Tanaka, Hiroyuki Suzuki, Guanjie Li, Ren Nanamiya, Nami Tateyama, Yu Isoda, Yuki Okada, Hiyori Kobayashi, Takeo Yoshikawa<\/strong><\/span>, Mika K. Kaneko, Yukinari Kato, Development of a Novel Anti-Mouse CCR6 Monoclonal Antibody (C6<\/sub>Mab-13) by N-Terminal Peptide Immunization, Monoclon Antib Immunodiagn Immunother, 41: 343-349, 2022 DOI: 10.1089\/mab.2022.0021<\/a>\n10. Hiroyuki Suzuki, Teizo Asano, Tomokazu Ohishi, Takeo Yoshikawa<\/strong><\/span>, Hiroyoshi Suzuki, Takuya Mizuno, Tomohiro Tanaka, Manabu Kawada, Mika K. Kaneko, Yukinari Kato, Antitumor Activities in Mouse Xenograft Models of Canine Fibroblastic Tumor by Defucosylated Mouse-Dog Chimeric Anti-HER2 Monoclonal Antibody (H77Bf), Monoclon Antib Immunodiagn Immunother, 42: 34-40, 2022, DOI: 10.1089\/mab.2022.0023<\/a>\n11. Tomohiro Tanaka, Hiroyuki Suzuki, Yu Isoda, Teizo Asano, Takuro Nakamura, Miyuki Yanaka, Saori Handa, Nozomi Takahashi, Saori Okuno, Takeo Yoshikawa<\/strong><\/span>, Guanjie Li, Ren Nanamiya, Nohara Goto, Nami Tatemiya, Yuki Okada, Hiyori Kobayashi, Mika K. Kaneko, Yukinari Kato, Development of a Sensitive Anti-Human CCR9 Monoclonal Antibody (C9<\/sub>Mab-11) by N-Terminal Peptide Immunization, Monoclon Antib Immunodiagn Immunother 41: 303-310, 2022, DOI: 10.1089\/mab.2022.0027<\/a>\n12. Yu Isoda, Tomohiro Tanaka, Hiroyuki Suzuki, Teizo Asano, Takeo Yoshikawa<\/strong><\/span>, Kaishi Kitamura, Yuma Kudo, Ryo Ejima, Kazuki Ozawa, Mika K. Kaneko, Yukinari Kato, Epitope Mapping Using the Cell-Based 2\u2009\u00d7\u2009Alanine Substitution Method About the Anti-mouse CXCR6 Monoclonal Antibody, Cx6<\/sub>Mab-1, Monoclon Antib Immunodiagn Immunother 42: 22-26, 2022, DOI: 10.1089\/mab.2022.0029<\/a>\n13. Tomohiro Tanaka, Hiroyuki Suzuki, Teizo Asano, Guanjie Li, Ren Nanamiya, Nami Tateyama, Yu Isoda, Yuki Okada, Hiyori Kobayashi, Takeo Yoshikawa<\/strong><\/span>, Mika K. Kaneko, Yukinari Kato, Epitope Mapping of an Anti-Mouse CCR2 Monoclonal Antibody (C2<\/sub>Mab-6) Using Enzyme-Linked Immunosorbent Assay, Monoclon Antib Immunodiagn Immunother, 41: 339-342, 2022, DOI: 10.1089\/mab.2022.0020<\/a>\n14. Masaki Saito, Hiroyuki Suzuki, Teizo Asano, Tomohiro Tanaka, Takeo Yoshikawa<\/strong><\/span>, Mika K. Kaneko, Yukinari Kato, KLMab-1: An Anti-human KLRG1 Monoclonal Antibody for Immunocytochemistry, Monoclon Antib Immunodiagn Immunother, 41: 279-284, 2022, DOI: 10.1089\/mab.2022.0016<\/a>\n15. Yu Isoda, Tomohiro Tanaka, Hiroyuki Suzuki, Teizo Asano, Takuro Nakamura, Miyuki Yanaka, Saori Handa, Yu Komatsu, Saori Okuno, Nozomi Takahashi, Yuki Okada, Hiyori Kobayashi, Guanjie Li, Ren Nanamiya, Nohara Goto, Nami Tatemiya, Takeo Yoshikawa<\/strong><\/span>, Mika K. Kaneko, Yukinari Kato, Epitope Mapping of an Anti-Mouse CXCR6 Monoclonal Antibody (Cx6<\/sub>Mab-1) Using the 2\u2009\u00d7\u2009Alanine Scanning Method, Monoclon Antib Immunodiagn Immunother, 41: 275-278, 2022, DOI: 10.1089\/mab.2022.0019<\/a>\n16. Tomohiro Tanaka, Hiroyuki Suzuki, Guanjie Li, Ren Nanamiya, Yu Isoda, Yuki Okada, Hiyori Kobayashi, Takeo Yoshikawa<\/strong><\/span>, Mika K. Kaneko, Yukinari Kato, Epitope Mapping of the Anti-Human CC Chemokine Receptor Type-2 Monoclonal Antibody (K036C2), Monoclon Antib Immunodiagn Immunother, 41: 285-289, 2022, DOI: 10.1089\/mab.2022.0018<\/a>\n17. Hiroyuki Suzuki, Tomokazu Ohishi, Teizo Asano, Tomohiro Tanaka, Masaki Saito, Takuya Mizuno, Takeo Yoshikawa<\/strong><\/span>, Manabu Kawada, Mika Kaneko, Yukinari Kato, Defucosylated mouse\u2011dog chimeric anti\u2011HER2 monoclonal antibody exerts antitumor activities in mouse xenograft models of canine tumors, Oncol Rep 48: 154, 2022, DOI: 10.3892\/or.2022.8366<\/a> <\/pre>\n\n\n\n
2021<\/h2>\n\n\n\n
1. Matsuzawa T, Morita M, Shimane A, Otsuka R, Mei Y, Irie F, Yamaguchi Y, Yanai K, Yoshikawa T<\/strong>*<\/span> Heparan sulfate promotes differentiation of white adipocytes to maintain insulin sensitivity and glucose homeostasis. J Biol Chem 297: 101006, 2021 \n2. Naganuma F<\/strong><\/span>, Nakamura T, Kuroyanagi H, Tanaka M, Yoshikawa T<\/strong><\/span>, Yanai K, Okamura N. Chemogenetic modulation of histaminergic neurons in the tuberomamillary nucleus alters territorial aggression and wakefulness. Sci Rep 11: 17935, 2021\n3. Naganuma F<\/strong><\/span>, Yoshikawa T*<\/strong><\/span>. Organic Cation Transporters in Brain Histamine Clearance: Physiological and Psychiatric Implications. Handb Exp Pharmacol 266:169-185, 2021\n4. Yoshikawa T*<\/strong><\/span>, Nakamura T, Yanai K. Histaminergic neurons in the tuberomammillary nucleus as a control centre for wakefulness. Br J Pharmacol 178: 750-769, 2021\n5. Yanai K, Yoshikawa T<\/strong><\/span>, Church MK, Efficacy and Safety of Non-brain Penetrating H 1-Antihistamines for the Treatment of Allergic Diseases. Curr Top Behav Neurosci 2022, 59: 193-214 <\/pre>\n\n\n\n
2020<\/h2>\n\n\n\n
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1. Yamada Y, Yoshikawa T*<\/strong><\/span>, Naganuma F<\/strong><\/span>, Kikkawa T, Osumi N, Yanai K. Chronic brain histamine depletion in adult mice induced depression-like behaviours and impaired sleep-wake cycle. Neuropharmacology 175: 108179, 2020 (*: corresponding author)\n2. Yokoyama M, Matsuzawa T, Yoshikawa T*<\/strong><\/span>, Nunomiya A, Yamaguchi Y, Yanai K. Heparan sulfate controls skeletal muscle differentiation and motor functions. Biochim Biophys Acta Gen Subj 1864: 129707, 2020<\/pre>\n\n\n\n
2019<\/h2>\n\n\n\n
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1. K\u00e1rp\u00e1ti A, Yoshikawa T*<\/strong><\/span>, Naganuma F<\/strong><\/span>, Matsuzawa T, Kitano H, Yamada Y, Yokoyama M, Futatsugi A, Mikoshiba K, Yanai K. Histamine H1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour. Sci Rep 9(1):16451, 2019 (*: corresponding author)\n2\uff0eNakamura T, Hiraoka K, Harada R, Matsuzawa T, Ishikawa Y, Funaki Y, Yoshikawa T<\/strong><\/span>, Tashiro M, Yanai K, Okamura N. Brain histamine H1 receptor occupancy after oral administration of desloratadine and loratadine. Pharmacol Res Perspect 7(4):e00499, 2019\n3. Naganuma F<\/span><\/strong>, Kroeger D, Bandaru S, Absi G, Madara J, Vetrivelan R, Lateral hypothalamic neurotensin neurons promote arousal and hyperthermia. PLos Biol 17(3): e3000172, 2019, DOI: 10.1371\/journal.pbio.3000172<\/a>\n4. Naganuma F<\/span><\/strong>, Bandaru S, Absi G, Chee M, Vetrivelan R, melanin-concentrating hormone neurons promote rapid eye movement sleep independent of glutamate release, Brain Struct Funct 224: 99-110, 2019 DOI: 10.1007\/s00429-018-1766-2<\/a>
5. Naganuma F, Bandaru S, Absi G, Mahoney C, Scammell T, Vetrivelan R, Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy. Neurobiol Dis 120: 12-20, 2018, DOI: 10.1016\/j.nbd.2018.08.012<\/a><\/pre>\n\n\n\n
2018\u4ee5\u524d<\/h2>\n\n\n\n
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1. Karpati A, Yoshikawa T*<\/strong><\/span>, Nakamura T, Iida T, Matsuzawa T, Kitano H, Harada R, Yanai K. Histamine elicits glutamate release from cultured astrocytes. J Pharmacol Sci 137: 122-128, 2018 (*: corresponding author)\n2. Matsuzawa T, Yoshikawa T*<\/strong><\/span>, Iida T, K\u00e1rp\u00e1ti A, Kitano H, Harada R, Nakamura T, Sugawara A, Yamaguchi Y, Yanai K. Heparan sulfate in pancreatic \u03b2-cells contributes to normal glucose homeostasis by regulating insulin secretion. Biochem Biophys Res Commun 499: 688-695, 2018 (*: corresponding author)\n3. Aoki S, Saito-Hakoda A, Yoshikawa T<\/strong><\/span>, Shimizu K, Kisu K, Takagi K, Mizumoto S, Yamada S, Kuppervelt T, Yokoyama A, Matusaka T, Sato H, Ito S, Sugawara A. The reduction of heparan sulphate in the glomerular basement membrane does not augment urinary albumin excretion. Nephrol Dial Transplant 33:26-33, 2018\n4. Eguchi K, Shindo T, Ito K, Ogata T, Kurosawa R, Kagaya Y, Monma Y, Ichijo S, Kasukabe S, Miyata S, Yoshikawa T<\/strong><\/span>, Yanai K, Taki H, Kanai H, Osumi N, Shimokawa H. Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia - Crucial roles of endothelial nitric oxide synthase. Brain Stimul 11: 959-973, 2018\n5. Yanai A, Harada R, Iwata R, Yoshikawa T<\/strong><\/span>, Ishikawa Y, Furumoto S, Ishida T, Yanai K. Site-Specific Labeling of F-18 Proteins Using a Supplemented Cell-Free Protein Synthesis System and O-2-[18F]Fluoroethyl-L-Tyrosine: [18F]FET-HER2 Affibody Molecule. Mol Imaging Biol 21: 529-537, 2018 \n6. Naganuma F<\/strong><\/span>, Nakamura T, Yoshikawa T*<\/strong><\/span>, Iida T, Miura Y, K\u00e1rp\u00e1ti A, Matsuzawa T, Yanai A, Mogi A, Mochizuki T, Okamura N, Yanai K. Histamine N-methyltransferase regulates aggression and the sleep-wake cycle. Sci Rep 7: 15899, 2017 (*: corresponding author)\n7. Inoue SI, Takahara S, Yoshikawa T<\/strong><\/span>, Niihori T, Yanai K, Matsubara Y, Aoki Y. Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice. Hum Mol Genet. 26: 4715-4727, 2017\n8. Yanai K, Yoshikawa T*<\/strong><\/span>, Yanai A, Nakamura T, Iida T, Leurs R, Tashiro M. The clinical pharmacology of non-sedating antihistamines. Pharmacol Ther. 178: 148-156, 2017  (*: corresponding author)\n9. Kishimoto Y, Asakawa S, Sato T, Takano T, Nakajyo T, Mizuno N, Segawa R, Yoshikawa T<\/strong><\/span>, Hiratsuka M, Yanai K, Ohtsu H, Hirasawa N. Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration. Exp Dermatol. 26: 868-874, 2017 \n10. Yoshikawa T*<\/strong><\/span> and Yanai K, Histamine clearance through polyspecific transporters in the brain. Handbook Exp Pharmacol 241: 173-187, 2017 (*: corresponding author) \n11. Miura Y, Yoshikawa T*<\/strong><\/span>, Naganuma F<\/strong><\/span>, Nakamura T, Iida T, K\u00e1rp\u00e1ti A, Matsuzawa T, Mogi A, Harada R, Yanai K. Characterization of murine polyspecific monoamine transporters. FEBS Open Bio 7: 237-248, 2017 (*: corresponding author)\n12. Iida T, Yoshikawa T*<\/strong><\/span>, K\u00e1rp\u00e1ti A, Matsuzawa T, Kitano H, Mogi A, Harada R, Naganuma F<\/strong><\/span>, Nakamura T, Yanai K. JNJ10181457, a histamine H3 receptor inverse agonist, regulates in vivo microglial functions and improves depression-like behaviours in mice. Biochem Biophys Res Commun. 488: 534-540, 2017 (*: corresponding author)\n13. Harada R, Furumoto S, Yoshikawa T<\/strong><\/span>, Ishikawa Y, Shibuya K, Okamura N, Ishiwata K, Iwata R, Yanai K. Synthesis and Characterization of 18F-Interleukin-8 Using a Cell-Free Translation System and 4-18F-Fluoro-l-Proline J Nucl Med 57: 634-639, 2016\n14. Saito-Hakoda A, Uruno A, Yokoyama A, Shimizu K, Parvin R, Kudo M, Saito-Ito T, Sato I, Kogure N, Suzuki D, Shimada H, Yoshikawa T<\/strong><\/span>, Fujiwara I, Kagechika H, Iwasaki Y, Kure S, Ito S, Sugawara A. Effects of RXR Agonists on Cell Proliferation\/Apoptosis and ACTH Secretion\/Pomc Expression. PLoS One 10: e0141960, 2015\n15. Sato H, Ito C, Hiraoka K, Tashiro M, Shibuya K, Funaki Y, Yoshikawa T<\/strong><\/span>, Iwata R, Matsuoka H, Yanai K. Histamine H1 receptor occupancy by the new-generation antipsychotics olanzapine and quetiapine: a positron emission tomography study in healthy volunteers. Psychopharmacology (Berl) 232: 3497-3505, 2015\n16. Iida T, Yoshikawa T*<\/strong><\/span>, Matsuzawa T, Naganuma F<\/strong><\/span>, Nakamura T, Miura Y, Mohsen AS, Harada R, Iwata R, Yanai K. Histamine H3 receptor in primary mouse microglia inhibits chemotaxis, phagocytosis, and cytokine secretion. Glia 63: 1213-1225, 2015 (*: corresponding author)\n17. Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T<\/strong><\/span>, Tago T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y. [(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease, Eur J Nucl Med Mol Imaging 42: 1052-61, 2015 \n18. Murakami M, Yoshikawa T<\/strong><\/span>, Nakamura T, Ohba T, Matsuzaki Y, Sawamura D, Kuwasako K, Yanagisawa T, Ono K, Nakaji S, Yanai K. Involvement of the histamine H1 receptor in the regulation of sympathetic nerve activity. Biochem Biophys Res Commun 458: 584-589, 2015\n19. Suzuki H, Sumiyoshi A, Matsumoto Y, Duffy BA, Yoshikawa T<\/strong><\/span>, Lythgoe MF, Yanai K, Taki Y, Kawashima R, Shimokawa H. Structural abnormality of the hippocampus associated with depressive symptoms in heart failure rats. Neuroimage 105: 84-92, 2015\n20. Kasajima A, Fujishima F, Morikawa T, Kawasaki S, Konosu-Fukaya S, Shibahara Y, Nakamura T, Yoshikawa T<\/strong><\/span>, Iijima K, Koike T, Watanabe M, Shibata C, Sasano H. G-cell hyperplasia of the stomach induces ECL-cell proliferation in the pyloric glands in a paracrinal manner. Pathol Int 65: 259-263, 2015\n21. Yoshikawa T<\/strong><\/span>, Nakamura T, Shibakusa T, Sugita M, Naganuma F<\/strong><\/span>, Iida T, Miura Y, Mohsen A, Harada R, Yanai K. Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice. J Nutr 144: 1637-1641, 2014\n22. Nakamura T, Yoshikawa T*<\/strong><\/span>, Naganuma F, Mohsen A, Iida T, Miura Y, Sugawara A, Yanai K. Role of histamine H3 receptor in glucagon-secreting \u03b1TC1.6 cells. FEBS Open Bio 5: 36-41, 2014  (*: corresponding author)\n23. Naganuma F<\/strong><\/span>, Yoshikawa T*<\/strong><\/span>, Nakamura T, Iida T, Harada R, Mohsen A, Yamato M, Yanai K, Predominant role of plasma membrane monoamine transporters in monoamine transport in 1321N1, a human astrocytoma-derived cell line.  J Neurochem 129: 591-601, 2014 (*: corresponding author)\n24. Mohsen A, Yoshikawa T*<\/strong><\/span>, Miura Y, Nakamura T, Naganuma F<\/strong><\/span>, Shibuya K, Iida T, Harada R, Okamura N, Watanabe T, Yanai K, Mechanism of the Histamine H3 Receptor-mediated Increase in Exploratory Locomotor Activity and Anxiety-like Behaviours in Mice. Neuropharmacology 81: 188-194, 2014 (*: corresponding author)\n25. Nakamura T**, Yoshikawa T*<\/strong><\/span>, **, Noguchi N, Sugawara A, Kasajima A, Sasano H, Yanai K, The expression and function of histamine H3 receptor in pancreatic \u03b2-cells, Br J Pharamacol 171: 171-185, 2014 (*: corresponding author, **: co-first author)\n26. Matsuda K, Uruno A, Kogure N, Sugawara K, Shimada H, Nezu M, Saito-Ito T, Iki Y, Kudo M, Shimizu K, Sato I, Yoshikawa T<\/strong><\/span>, Satoh F, Ito R, Yokoyama A, Rainey WE, Saito-Hakoda A, Ito S, Sugawara A. Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells. Mol Cell Endocrinol 383: 60-68, 2014\n27. Guo Y, Niu K, Okazaki T, Wu H, Yoshikawa T<\/strong><\/span>, Ohrui T, Furukawa K, Ichinose M, Yanai K, Arai H, Huang G, Nagatomi R. Coffee treatment prevents the progression of sarcopenia in aged mice in vivo and in vitro. Exp Gerontol 50: 1-8, 2014\n28. Harada R, Okamura N, Furumoto S, Yoshikawa T<\/strong><\/span>, Arai H, Yanai K, Kudo Y, Use of benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of Tau protein fibrils in the Alzheimer\u2019s disease brain, Mol Imaging Biol 16: 19-27, 2014\n29. Uruno A, Saito-Hakoda A, Yokoyama A, Kogure N, Matsuda K, Parvin R, Shimizu K, Sato I, Kudo M, Yoshikawa T<\/strong><\/span>, Kagechika H, Iwasaki Y, Ito S, Sugawara A. Retinoic acid receptor-\u03b1 up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells. Endocr J 61: 1105-1114, 2014\n30. Yoshikawa T*<\/strong><\/span>, Naganuma F<\/strong><\/span>, Iida T, Nakamura T, Harada R, Mohsen A, Kasajima A, Sasano H, Yanai K, Molecular mechanism of histamine clearance by primary human astrocytes, Glia 61: 905-916, 2013 (*: corresponding author)\u3000\n31. Okamura N, Furumoto S, Harada R, Tago T, Yoshikawa T<\/strong><\/span>, Fodero-Tavoletti M, Mulligan RS, Villemange VL, Akatsu, H, Yamamoto T, Arai H, Iwata R, Yanai K, Kudo Y, Novel 18F-labeled arylqunoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease, J Nucl Med 54: 1420-1427, 2013 \n32. Harada R, Okamura N, Furumoto S, Tago T, Maruyama M, Higuchi M, Yoshikawa T<\/strong><\/span>, Arai H, Iwata R, Kudo Y, Yanai K, Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer\u2019s disease pathology, Eur J Nucl Med Mol Imaging 40: 125-132, 2013\u3000\n33. Shibuya K, Funaki Y, Hiraoka K, Yoshikawa T<\/strong><\/span>, Naganuma F<\/strong><\/span>, Miyake M, Watanuki S, Sato H, Tashiro M, Yanai K, [(11)C]doxepin binding to histamine H1 receptor s in living human brain: reproducibility during attentive waking and circadian rhythm, Front Syst Neurosci, 6 :45, 2012\n34. Ikeda T, Takasawa S, Noguchi N, Nata K, Yamauchi A, Takahashi I, Yoshikawa T<\/strong><\/span>, Sugawara A, Yonekura H, Okamoto H, Identification of a major enzyme for the synthesis and hydrolysis of cylic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate, Mol Cell Biochem, 366: 69-80 2012\u3000\n35. 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Okuda T, Zhang D, Shao H, Okamura N, Takino N, Iwamura T, Sakurai E, Yoshikawa T<\/strong><\/span>, Yanai K, Methamphetamine- and 3,4-Methylenedioxymethamphetamine-induced behavioral changes in histamine knockout mice. J Pharmacol Sci, 111: 167-174, 2009 \n45. Takahashi I, Noguchi N, Nata K, Yamada S, Kaneiwa T, Mizumoto S, Ikeda T, Sugihara K, Asano M, Yoshikawa T<\/strong><\/span>, Yamauchi A, Shervani NJ, Uruno A, Kato I, Unno M, Sugahara K, Takasawa S, Okamoto H, Sugawara A, Important role of heparan sulfate in postnatal islet growth and insulin secretion. Biochem Biophys Res Commun 383: 113-8, 2009\n46. Yamauchi A, Takahashi I, Takasawa S, Nata K, Noguchi N, Ikeda T, Yoshikawa T<\/strong><\/span>, Shervani NJ, Suzuki I, Uruno A, Unno M, Okamoto H, Sugawara A, Thiazolidinediones inhibit REG Ialpha gene transcription in gastrointestinal cancer cells. Biochem Biophys Res Commun 379: 743-748, 2009\n47. *Noguchi N, *Yoshikawa T<\/strong><\/span>, Ikeda T, Takahashi I, Shervani NJ, Uruno A, Yamauchi A, Nata K, Takasawa S, Okamoto H, Sugawara A, FKBP12.6 disruption impairs glucose-induced insulin secretion. Biochem Biophys Res Commun 371: 735-740, 2008 (*: co-first author)\n48. Nakazawa T, Takasawa S, Noguchi N, Nata K, Tohgo A, Mori M, Nakagawara K, Akiyama T, Ikeda T, Yamauchi A, Takahashi I, Yoshikawa T<\/strong><\/span>, Okamoto H, Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6, Gene 360: 55-64, 2005 \n<\/pre>\n","protected":false},"excerpt":{"rendered":"
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