{"id":338,"date":"2023-12-27T16:45:17","date_gmt":"2023-12-27T07:45:17","guid":{"rendered":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/?page_id=338"},"modified":"2024-01-19T10:09:03","modified_gmt":"2024-01-19T01:09:03","slug":"gag","status":"publish","type":"page","link":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/gag.html","title":{"rendered":"\u7cd6\u9396"},"content":{"rendered":"\n<p class=\"has-small-font-size\">\u30d8\u30d1\u30e9\u30f3\u786b\u9178\uff08heparan sulfate; HS\uff09\u306f\uff12\u7cd6\u306e\u7e70\u308a\u8fd4\u3057\u69cb\u9020\u3092\u6709\u3059\u308b\u76f4\u9396\u72b6\u7cd6\u9396\u3067\u3059\u3002\u30d8\u30d1\u30e9\u30f3\u786b\u9178\u306f\u30b0\u30ea\u30d4\u30ab\u30f3\u3084\u30b7\u30f3\u30c7\u30ab\u30f3\u306a\u3069\u306e\u30b3\u30a2\u86cb\u767d\u8cea\u3068\u7d50\u5408\u3057\u3001\u30d8\u30d1\u30e9\u30f3\u786b\u9178\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\uff08heparan sulfate proteoglycans; HSPGs\uff09\u3068\u547c\u3070\u308c\u308b\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3066\u3044\u307e\u3059\u3002HSPG\u306f\u591a\u304f\u306e\u7d44\u7e54\u306e\u7d30\u80de\u819c\u3084\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306b\u5b58\u5728\u3057\u3001\u69d8\u3005\u306a\u6a5f\u80fd\u3092\u767a\u63ee\u3057\u3066\u3044\u307e\u3059\u3002\u4f53\u8868\u7684\u306a\u6a5f\u80fd\u3068\u3057\u3066\u306f\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u3084\u60c5\u5831\u4f1d\u9054\u3001\u7d30\u80de\u63a5\u7740\u3001\u7d30\u80de\u5916\u304b\u3089\u306e\u7269\u8cea\u8f38\u9001\u306a\u3069\u304c\u3042\u3052\u3089\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u7d30\u80de\u819c\u8868\u9762\u306b\u786b\u9178\u57fa\u306b\u5bcc\u3093\u3060HS\u304c\u5b58\u5728\u3059\u308b\u3068\u3001\u6b63\u96fb\u8377\u3092\u6709\u3059\u308b\u30ea\u30ac\u30f3\u30c9\uff08heparan sulfate binding proteins; HSBP\uff09\u304cHS\u306e\u8ca0\u96fb\u8377\u306b\u5f15\u304d\u5bc4\u305b\u3089\u308c\u3066\u3001\u819c\u8fd1\u508d\u3078\u3068\u96c6\u7a4d\u3057\u3001\u7d50\u679c\u3068\u3057\u3066\u30ea\u30ac\u30f3\u30c9\u3068\u53d7\u5bb9\u4f53\u3068\u306e\u7d50\u5408\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306bHS\u304c\u5171\u5f79\u53d7\u5bb9\u4f53\u3068\u3057\u3066HSBP\u306b\u3088\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u5897\u5f37\u3055\u305b\u308b\u3053\u3068\u306f\u3001\u7d30\u80de\u5897\u6b96\u3084\u5206\u5316\u306a\u3069\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u5927\u304d\u306a\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\uff08<a rel=\"noreferrer noopener\" href=\"https:\/\/www.nature.com\/articles\/nature05817\" target=\"_blank\">Bishop et al, 2007<\/a>,&nbsp;<a rel=\"noreferrer noopener\" href=\"https:\/\/cshperspectives.cshlp.org\/content\/3\/7\/a004952.long\" target=\"_blank\">Sarrazin et al, 2011<\/a>\uff09\u3002<\/p>\n\n\n\n<p class=\"has-small-font-size\">\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001HS\u3068\u7cd6\u5c3f\u75c5\u3068\u306e\u95a2\u9023\u306b\u7740\u76ee\u3057\u305f\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u904e\u53bb\u306e\u5831\u544a\u3067\u306f\u3001\u2460HS\u5408\u6210\u9175\u7d20\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3042\u308b\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u6e1b\u5c11\u50be\u5411\u306b\u3042\u308b\u3053\u3068\uff08<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0115662\" target=\"_blank\" rel=\"noreferrer noopener\">Moens, et al, 2014<\/a>\uff09\u3001\u2461\uff11\u578b\u7cd6\u5c3f\u75c5\u304c\u9032\u884c\u3059\u308b\u3068\u81b5\u03b2\u7d30\u80de\u306eheparanase\uff08HS\u5206\u89e3\u9175\u7d20\uff09\u6d3b\u6027\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\uff08<a href=\"https:\/\/www.jci.org\/articles\/view\/46177\" target=\"_blank\" rel=\"noreferrer noopener\">Ziolkowski, et al, 2011<\/a>\uff09\u3001\u2462\uff12\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3055\u3093\u306e\u8840\u6db2\u4e2dheparanase\u304c\u5897\u52a0\u50be\u5411\u306b\u3042\u308b\u3053\u3068\uff08<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0017312\" target=\"_blank\" rel=\"noreferrer noopener\">Shafat I, et al, 2011<\/a>&nbsp;\uff09\u3001\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u2463\uff12\u578b\u7cd6\u5c3f\u75c5\u3068HS\u5408\u6210\u9175\u7d20\u5909\u7570\u3068\u306e\u95a2\u9023\u3092\u793a\u5506\u3059\u308b\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\u7d50\u679c\uff08<a href=\"https:\/\/www.nature.com\/articles\/nature05616\" target=\"_blank\" rel=\"noreferrer noopener\">Sladek et al,2007<\/a>\uff09\u3082\u8907\u6570\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5831\u544a\u306f\u3001\u5168\u8eab\u306e\u30d6\u30c9\u30a6\u7cd6\u4ee3\u8b1d\u306bHS\u304c\u4f55\u3089\u304b\u306e\u5f62\u3067\u95a2\u308f\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u8840\u7cd6\u5024\u306e\u5236\u5fa1\u306b\u95a2\u308f\u308b\u81b5\u03b2\u7d30\u80de\u3084\u9aa8\u683c\u7b4b\u3001\u8102\u80aa\u7d30\u80de\u3001\u809d\u81d3\u306a\u3069\u306b\u304a\u3044\u3066HS\u304c\u3069\u306e\u3088\u3046\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u306e\u304b\u306f\u4e0d\u660e\u306e\u307e\u307e\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"has-small-font-size\">\u305d\u3053\u3067\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u81d3\u5668\u306b\u304a\u3051\u308bHS\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u81b5\u03b2\u7d30\u80de\u3084\u767d\u8272\u8102\u80aa\u7d30\u80de\u3067HS\u304c\u6b20\u640d\u3059\u308b\u3068\u8010\u7cd6\u80fd\u7570\u5e38\u3092\u304d\u305f\u3059\u3053\u3068\uff08<a href=\"https:\/\/doi.org\/10.1016\/j.bbrc.2018.03.213\" target=\"_blank\" rel=\"noreferrer noopener\">Matsuzawa T, et al, 2018<\/a>,&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.jbc.2021.101006\" target=\"_blank\" rel=\"noreferrer noopener\">Matsuzawa T, et al, 2021<\/a>\uff09\u3001\u9aa8\u683c\u7b4b\u3067HS\u304c\u6b20\u640d\u3059\u308b\u3068\u904b\u52d5\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\uff08<a href=\"https:\/\/doi.org\/10.1016\/j.bbagen.2020.129707\" target=\"_blank\" rel=\"noreferrer noopener\">Yokoyama M, et al, 2020<\/a>\uff09\u3092\u5831\u544a\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u5f93\u3063\u3066\u3001HS\u304c\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u3067\u5404\u81d3\u5668\u306f\u6b63\u5e38\u306b\u6a5f\u80fd\u3057\u3066\u3044\u308b\u3053\u3068\u3001HS\u306e\u6e1b\u5c11\u3084\u6b20\u640d\u306f\u6a5f\u80fd\u4f4e\u4e0b\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u73fe\u5728\u79c1\u9054\u306f\u3001\u5404\u7d44\u7e54\u306b\u304a\u3044\u3066HS\u3092\u5897\u52a0\u3055\u305b\u308b\u3068\u6a5f\u80fd\u5411\u4e0a\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u3092\u8003\u3048\u3066\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002HS\u306e\u5897\u52a0\u306b\u3088\u308a\u7d44\u7e54\u6a5f\u80fd\u304c\u4ea2\u9032\u3059\u308c\u3070\u3001\u8010\u7cd6\u80fd\u3084\u904b\u52d5\u6a5f\u80fd\u304c\u5411\u4e0a\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3053\u306e\u3088\u3046\u306a\u7d50\u679c\u3092\u57fa\u306bHS\u3092\u6a19\u7684\u3068\u3057\u305f\u5275\u85ac\u7814\u7a76\u3078\u3068\u3064\u306a\u3052\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u306f\u7c73\u56fdSanford Burnham Prebys Medical Discovery Institute\u306e<a href=\"https:\/\/www.sbpdiscovery.org\/our-scientists\/yu-yamaguchi-md-phd\" target=\"_blank\" rel=\"noreferrer noopener\">Yamaguchi\u6559\u6388<\/a>\u3068\u5171\u540c\u3067\u5b9f\u65bd\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30d8\u30d1\u30e9\u30f3\u786b\u9178\uff08heparan sulfa &hellip; <\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/pages\/338"}],"collection":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/comments?post=338"}],"version-history":[{"count":5,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/pages\/338\/revisions"}],"predecessor-version":[{"id":638,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/pages\/338\/revisions\/638"}],"wp:attachment":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/media?parent=338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}