{"id":330,"date":"2023-12-27T16:35:54","date_gmt":"2023-12-27T07:35:54","guid":{"rendered":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/?page_id=330"},"modified":"2024-01-15T19:06:15","modified_gmt":"2024-01-15T10:06:15","slug":"histamine","status":"publish","type":"page","link":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/histamine.html","title":{"rendered":"Histamine"},"content":{"rendered":"\n<p class=\"has-small-font-size\">\u30d2\u30b9\u30bf\u30df\u30f3\u306f\u30011911\u5e74\u306b\u82f1\u56fd\u306e<a rel=\"noreferrer noopener\" href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/1936\/dale\/biographical\/\" target=\"_blank\">Sir Henry Dale\u5148\u751f<\/a>\u306b\u3088\u308a\u767a\u898b\u3055\u308c\u305f\u751f\u7406\u6d3b\u6027\u7269\u8cea\u3067\u3059\u3002\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3084\u80c3\u9178\u5206\u6ccc\u306b\u95a2\u308f\u308b\u751f\u7406\u6d3b\u6027\u7269\u8cea\u3068\u3057\u3066\u5e83\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8133\u5185\u3067\u306f\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u899a\u9192\u3084\u5b66\u7fd2\u8a18\u61b6\u3001\u98df\u6b32\u8abf\u7bc0\u306a\u3069\u306b\u95a2\u308f\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u3067\u306f\u30d2\u30b9\u30bf\u30df\u30f3\u91cf\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9466423\/\">Panula P, et al, 1998<\/a>\uff09\u3001\u307e\u305f\u30d2\u30b9\u30bf\u30df\u30f3\u5408\u6210\u9175\u7d20\uff08histidine decarboxylase\uff09\u306e\u907a\u4f1d\u5b50\u7570\u5e38\u306fTourette\u75c7\u5019\u7fa4\u306e\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\uff08<a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24411733\/\" target=\"_blank\">Balden et al, 2014<\/a>\uff09\u3002\u4e00\u65b9\u3067\u3001\u30d2\u30b9\u30bf\u30df\u30f3\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\u306e\u907a\u4f1d\u5b50\u7570\u5e38\u304c\u3042\u308b\u3068\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u7f79\u60a3\u7387\u304c\u4f4e\u3044\u3053\u3068\u3082\u5831\u544a\u3055\u308c\uff08<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27399132\/\">Jim\u00e9nez-Jim\u00e9nez FJ, et al, 2016<\/a>\uff09\u3001\u8133\u5185\u306e\u30d2\u30b9\u30bf\u30df\u30f3\u304c\u5c11\u306a\u3044\u3068\u75c5\u6c17\u306b\u306a\u308a\u3084\u3059\u304f\u3001\u8133\u5185\u30d2\u30b9\u30bf\u30df\u30f3\u304c\u591a\u3044\u3068\u75c5\u6c17\u306b\u5bfe\u3057\u3066\u4e88\u9632\u7684\u306b\u50cd\u304f\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-small-font-size\">\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u306b\u304a\u3044\u3066\u8133\u5185\u306e\u30d2\u30b9\u30bf\u30df\u30f3\u795e\u7d4c\u7cfb\u306e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u75c5\u614b\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1093\/sleep\/zsaa095\" target=\"_blank\">Shimada M, et al, 2020<\/a>\uff09\u3002\u305d\u3053\u3067\u6211\u3005\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u8133\u5185\u306e\u30d2\u30b9\u30bf\u30df\u30f3\u795e\u7d4c\u7cfb\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u3092\u6cbb\u7642\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-wide\"\/>\n\n\n\n<p><strong>\u2460\u30d2\u30b9\u30bf\u30df\u30f3\u795e\u7d4c\u7cfb\u306e\u6d3b\u6027\u5316\u306b\u3088\u308b\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u6cbb\u7642<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\">\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u306f\u65e5\u4e2d\u306e\u6d3b\u52d5\u6642\u9593\u5e2f\u306b\u7a81\u7136\u8010\u3048\u304c\u305f\u3044\u7720\u6c17\u304c\u751f\u3058\u308b\u904e\u7720\u75c7\u306e1\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u306e\u60a3\u8005\u3055\u3093\u3067\u306f\u30aa\u30ec\u30ad\u30b7\u30f3\u3068\u3044\u3046\u899a\u9192\u306b\u6975\u3081\u3066\u91cd\u8981\u306a\u795e\u7d4c\u30da\u30d7\u30c1\u30c9\u304c\u5927\u304d\u304f\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8133\u5185\u306e\u30d2\u30b9\u30bf\u30df\u30f3\u3082\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1093\/sleep\/32.2.175\" target=\"_blank\">Nishino S, et al, 2009,<\/a> <a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1111\/j.1365-2869.2010.00819.x\" target=\"_blank\">Bassetti, CL, el al, 2010<\/a>, <a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1093\/sleep\/zsaa095\" target=\"_blank\">Shimada M, et al, 2020<\/a>\uff09\u3002\u5f93\u3063\u3066\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u3067\u6e1b\u5c11\u3057\u3066\u3044\u308b\u8133\u5185\u30d2\u30b9\u30bf\u30df\u30f3\u3092\u85ac\u7269\u306b\u3088\u308b\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u51fa\u6765\u308c\u3070\u3001\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u306e\u904e\u7720\u75c7\u72b6\u3092\u6539\u5584\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u6211\u3005\u306e\u7814\u7a76\u306b\u3088\u308a\u8133\u5185\u306e\u30d2\u30b9\u30bf\u30df\u30f3\u6fc3\u5ea6\u306f\u30d2\u30b9\u30bf\u30df\u30f3\u3092\u4ee3\u8b1d\u3059\u308bHNMT\uff08histamine N-methyltransferase\uff09\u306b\u3088\u308a\u8abf\u7bc0\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\uff08<a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1038\/s41598-017-16019-8\" target=\"_blank\">Naganuma F, et al, 2017<\/a>\uff09\u3002HNMT\u306e\u6a5f\u80fd\u3092\u6291\u5236\u3059\u308b\u85ac\u7269\u306f\u30d2\u30b9\u30bf\u30df\u30f3\u6fc3\u5ea6\u3092\u5897\u52a0\u3055\u305b\u3066\u30ca\u30eb\u30b3\u30ec\u30d7\u30b7\u30fc\u75c7\u72b6\u3092\u548c\u3089\u3052\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u308b\u3053\u3068\u304b\u3089\u3002\u73fe\u5728HNMT\u306b\u5bfe\u3059\u308b\u963b\u5bb3\u85ac\u306e\u958b\u767a\u3092<a rel=\"noreferrer noopener\" href=\"http:\/\/www.pharm.tohoku.ac.jp\/~gousei\/synthetic\/index.php\" target=\"_blank\">\u6771\u5317\u5927\u5b66\u85ac\u5b66\u90e8<\/a>\u3084<a rel=\"noreferrer noopener\" href=\"http:\/\/www.agr.kyushu-u.ac.jp\/lab\/nouyaku\/index.html\" target=\"_blank\">\u4e5d\u5dde\u5927\u5b66\u8fb2\u5b66\u90e8<\/a>\u3001<a rel=\"noreferrer noopener\" href=\"https:\/\/tmpu-pharmacol.org\" target=\"_blank\">\u6771\u5317\u533b\u79d1\u85ac\u79d1\u5927\u5b66\u533b\u5b66\u90e8<\/a>\u306e\u5148\u751f\u65b9\u3068\u5171\u540c\u3067\u5b9f\u65bd\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"262\" src=\"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-content\/uploads\/2024\/01\/795316b92fc766b0181f6fef074f03fa-1024x262.png\" alt=\"\" class=\"wp-image-522\" srcset=\"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-content\/uploads\/2024\/01\/795316b92fc766b0181f6fef074f03fa-1024x262.png 1024w, https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-content\/uploads\/2024\/01\/795316b92fc766b0181f6fef074f03fa-300x77.png 300w, https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-content\/uploads\/2024\/01\/795316b92fc766b0181f6fef074f03fa-768x196.png 768w, https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-content\/uploads\/2024\/01\/795316b92fc766b0181f6fef074f03fa-1536x392.png 1536w, https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-content\/uploads\/2024\/01\/795316b92fc766b0181f6fef074f03fa.png 1808w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>\u2461\u30d2\u30b9\u30bf\u30df\u30f3\u7cfb\u306e\u6a5f\u80fd\u89e3\u660e<\/p>\n\n\n\n<p class=\"has-small-font-size\">\u30d2\u30b9\u30bf\u30df\u30f3\u306f\u53e4\u304f\u304b\u3089\u30a2\u30ec\u30eb\u30ae\u30fc\u306a\u3069\u306b\u95a2\u308f\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8133\u5185\u3067\u306e\u30d2\u30b9\u30bf\u30df\u30f3\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u304c\u672c\u683c\u7684\u306b\u59cb\u307e\u3063\u305f\u306e\u306f1980\u5e74\u4ee3\u304b\u3089\u3067\uff08<a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1016\/0304-3940(83)90308-7\" target=\"_blank\">Watanabe T, et al, 1983<\/a>\uff09\u3001\u30c9\u30d1\u30df\u30f3\u3084\u30bb\u30ed\u30c8\u30cb\u30f3\u306a\u3069\u3068\u6bd4\u3079\u308b\u3068\u307e\u3060\u307e\u3060\u672a\u89e3\u660e\u306e\u70b9\u304c\u591a\u304f\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u30d2\u30b9\u30bf\u30df\u30f3\u304c\u5f37\u3044\u899a\u9192\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u306f\u5e83\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u899a\u9192\u306b\u91cd\u8981\u306a\u795e\u7d4c\u56de\u8def\u3084REM\u7761\u7720\/NREM\u7761\u7720\u3078\u306e\u5f71\u97ff\u306a\u3069\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u307e\u3060\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u307e\u305f\u591a\u304f\u306e\u8133\u795e\u7d4c\u75be\u60a3\u3068\u30d2\u30b9\u30bf\u30df\u30f3\u7cfb\u7570\u5e38\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u8a73\u7d30\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u4e0d\u660e\u306e\u307e\u307e\u3067\u3059\u3002\u5f53\u6559\u5ba4\u3067\u306f\u69d8\u3005\u306a\u30d2\u30b9\u30bf\u30df\u30f3\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u6539\u5909\u52d5\u7269\u3084\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u64cd\u4f5c\u3001\u30aa\u30d7\u30c8\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3001\u30d5\u30a1\u30a4\u30d0\u30fc\u30d5\u30a9\u30c8\u30e1\u30c8\u30ea\u30fc\u306a\u3069\u3092\u7528\u3044\u306a\u304c\u3089\u30d2\u30b9\u30bf\u30df\u30f3\u795e\u7d4c\u7cfb\u306e\u5168\u5bb9\u89e3\u660e\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30d2\u30b9\u30bf\u30df\u30f3\u306f\u30011911\u5e74\u306b\u82f1\u56fd\u306eSir  &hellip; <\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/pages\/330"}],"collection":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/comments?post=330"}],"version-history":[{"count":13,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/pages\/330\/revisions"}],"predecessor-version":[{"id":560,"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/pages\/330\/revisions\/560"}],"wp:attachment":[{"href":"https:\/\/c-mng.cwh.hokudai.ac.jp\/pharmacology1.med\/Root\/wp-json\/wp\/v2\/media?parent=330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}